Acupuncture and IVF

Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis
We found very low to moderate level of evidence that acupuncture may improve pregnancy rate (RR = 1.23 95%CI[1.13, 1.34] P < 0.00001) and embryo transfer rate (RR = 2.04 95%CI[1.13, 3.70] P = 0.02), increase trilinear endometrium (RR = 1.47 95%CI [1.27, 1.70] P < 0.00001), thicken endometrium (SMD = 0.41 95% CI [0.11, 0.72] P = 0.008), reduce resistive index (RI) (MD = -0.08 95% CI [− 0.15, − 0.02] P = 0.01), pulse index (PI) (SMD = -2.39 95% CI [− 3.85, − 0.93] P = 0.001) and peak systolic velocity/ end-diastolic blood velocity (S/D) (SMD = -0.60 95% CI [− 0.89, − 0.30] P < 0.0001), compared with medication, sham acupuncture or physiotherapy. Acupuncture was statistically significant as a treatment approach.
Published on March 13, 2019

Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial.
Fertil Steril. 2006 May;85(5):1341-6. Epub 2006 Apr 5. Westergaard LG, Mao Q, Krogslund M, Sandrini S, Lenz S, Grinsted J. – Fertility Clinic Trianglen, Hellerup, Denmark. CONCLUSION(S): Acupuncture on the day of ET significantly improves the reproductive outcome of IVF/ICSI, compared with no acupuncture. Repeating acupuncture on ET day +2 provided no additional beneficial effect.
Published on April 5, 2006

Acupuncture performed around the time of embryo transfer: a systematic review and meta-analysis
Smith CA et al. 2019. Acupuncture performed around the time of embryo transfer: a systematic review and meta-analysis. Reprod Biomed Online. 2019 Mar;38(3):364-379. doi: 10.1016/j.rbmo.2018.12.038. Epub 2019 Jan 2. CONCLUSIONS: Acupuncture may be effective when compared to no adjunctive treatment with increasing clinical pregnancies and live births, but is not an efficacious treatment when compared with sham controls. ("Sham acupuncture is not an effective control, because anytime you put a needle in the body you affect a change", Stephanie Gianarelli)
Published on March 1, 2019

Changes in serum cortisol and prolactin associated with acupuncture during controlled ovarian hyperstimulation in women undergoing in vitro fertilization-embryo transfer treatment.
Magarelli PC, Cridennda DK, Cohen M., Fertil Steril. 2009 Dec;92(6):1870-9. doi: 10.1016/j.fertnstert.2008.10.067. Epub 2008 Dec 31. CONCLUSION(S): In this study, there appears to be a beneficial regulation of CORT and PRL in the Ac group during the medication phase of the IVF treatment with a trend toward more normal fertile cycle dynamics.
Published on December 31, 2008

Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis
Zhang M, Niu W, Wang Y, et al. 2016. Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis. J Assist Reprod Genet. 33(8):981-991.
Published on August 1, 2016

DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve: A systematic review and meta-analysis
Schwarze JE, Canales J, Crosby J, Ortega-Hrepich C, Villa S, Pommer R. 2018. DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve: A systematic review and meta-analysis. JBRA Assist Reprod. 22(4):369-374.
Published on October 1, 2018

Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study.
Dieterle S, et al. Fertil Steril. 2006 May;85(5):1347-51. INTERVENTION(S): In group I, 116 patients received luteal-phase acupuncture according to the principles of traditional Chinese medicine. In group II, 109 patients received placebo acupuncture. MAIN OUTCOME MEASURE(S): Clinical and ongoing pregnancy rates. RESULT(S): In group I, the clinical pregnancy rate and ongoing pregnancy rate (33.6% and 28.4%, respectively) were significantly higher than in group II (15.6% and 13.8%). CONCLUSION(S): Luteal-phase acupuncture has a positive effect on the outcome of IVF/ICSI.
Published on May 1, 2006

Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis.
Manheimer E, Zhang G, Udoff L, Haramati A, Langenberg P, Berman BM, Bouter LM. BMJ. 2008 Mar 8;336(7643):545-9. doi: 10.1136/bmj.39471.430451.BE. Epub 2008 Feb 7. CONCLUSIONS: Current preliminary evidence suggests that acupuncture given with embryo transfer improves rates of pregnancy and live birth among women undergoing in vitro fertilisation.
Published on February 7, 2008

Impact of whole systems traditional Chinese medicine on in-vitro fertilization outcomes.
Hullender Rubin LE et al. 2015. Reproductive Biomedicine Online. 2015 Jun;30(6):602-12. Overall, IVF with adjuvant WS-TCM (whole-systems traditional Chinese medicine) was associated with greater odds of live birth in donor and non-donor cycles.
Published on June 30, 2015

Influence of acupuncture on the outcomes of in vitro fertilisation when embryo implantation has failed: a prospective randomised controlled clinical trial.
di Villahermosa DI, Dos Santos LG, Nogueira MB, Vilarino FL, Barbosa CP. Acupuncture in Medicine 2013 Jun;31(2):157-61. doi: 10.1136/acupmed-2012-010269. Epub 2013 Mar 19. Source: Faculty of Medicine of ABC, Clinic for Human Reproduction, Santo André, São Paulo, Brazil. RESULTS: The clinical pregnancy rate in the acupuncture group was significantly higher than that in the control and sham groups (35.7% vs 7.1% vs 10.7%; p=0.0169). CONCLUSIONS: In this study, acupuncture and moxibustion increased pregnancy rates when used as an adjuvant treatment in women undergoing IVF, when embryo implantation had failed.
Published on July 31, 2013

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