Male Factor Studies

A prospective randomized placebo-controlled study of the effect of acupuncture in infertile patients with severe oligoasthenozoospermia
Dieterle et al Fertil Steril 2009 Oct; 92 (4): Fertility and Sterility CONCLUSION(S): This recent small clinical trial randomized 57 patients who had extremely low sperm counts, to acupuncture and placebo acupuncture groups. After receiving acupuncture twice weekly for 6 weeks motility of sperm (but not overall count) was found to increase significantly. The authors conclude that the results of the present study support the significance of acupuncture in male patients with severe oligoasthenozoospermia. More evidence with larger trials needs to be accumulated before the efficacy and effectiveness of acupuncture in male infertility can be evaluated.
Published on Apr 25, 2009

Antioxidant supplements and semen parameters: An evidence based review
Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. 2016. Antioxidant supplements and semen parameters: An evidence based review. Int J Reprod Biomed. 14(12):729-736.
Published on Dec 14, 2016

Does acupuncture treatment affect sperm density in males with very low sperm count? A pilot study.
Siterman S, Eltes F, Wolfson V, Lederman H, Bartoov B., Andrologia. 2000 Jan;32(1):31-9. Source: Institute of Chinese Medicine, Tel Aviv, Israel. CONCLUSIONS: Acupuncture may be a useful, non-traumatic treatment for males with very poor sperm density, especially those with a history of genital tract inflammation.
Published on Jan 1, 2000

Does the Use of Mobile Phone Affect Male Fertility? A Mini-Review
Okechukwu CE. 2020. Does the Use of Mobile Phone Affect Male Fertility? A Mini-Review. J Hum Reprod Sci. 13(3):174-183.
Published on Jul 1, 2020

Effect of acupuncture on sperm parameters of males suffering from subfertility related to low sperm quality.
Siterman S, Eltes F, Wolfson V, Zabludovsky N, Bartoov B. Arch Androl. 1997 Sep-Oct;39(2):155-61. Source: Institute of Chinese Medicine, Tel Aviv, Israel. CONCLUSIONS: Patients exhibiting a low fertility potential due to reduced sperm activity may benefit from acupuncture treatment.
Published on Oct 1, 1997

Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study.
Dieterle S, et al. Fertil Steril. 2006 May;85(5):1347-51. INTERVENTION(S): In group I, 116 patients received luteal-phase acupuncture according to the principles of traditional Chinese medicine. In group II, 109 patients received placebo acupuncture. MAIN OUTCOME MEASURE(S): Clinical and ongoing pregnancy rates. RESULT(S): In group I, the clinical pregnancy rate and ongoing pregnancy rate (33.6% and 28.4%, respectively) were significantly higher than in group II (15.6% and 13.8%). CONCLUSION(S): Luteal-phase acupuncture has a positive effect on the outcome of IVF/ICSI.
Published on May 1, 2006

Effects of acupuncture and moxa treatment in patients with semen abnormalities.
Edson Gurfinkel, Agnaldo P. Cedenho, Ysao Yamamura, Miguel Srougi Human Reproduction Division, Discipline of Urology, Paulo Federal University, Paulista School of Medicine, Paulo, Brazil Asian J Androl 2003 Dec; 5: 345-348 CONCLUSION(S): The Chinese Traditional Medicine acupuncture and moxa techniques significantly increase the percentage of normal-form sperm in patients with oligoastenoteratozoospermia without apparent cause.
Published on Dec 1, 2003

Follicular fluid homocysteine levels with N-Acetyl cysteine supplemented controlled ovarian hyperstimulation, correlation with oocyte yield and ICSI cycle outcome
Hebisha, Sherif & Omran, M.S. & Sallam, Hassan & Ahmed, A.I.. 2015. Follicular fluid homocysteine levels with N-Acetyl cysteine supplemented controlled ovarian hyperstimulation, correlation with oocyte yield and ICSI cycle outcome. Fertility and Sterility. 104. e324. 10.1016/j.fertnstert.2015.07.1014.
Published on Sep 1, 2015

Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle
Mahmoudi R, Azizi A, Abedini S, Hemayatkhah Jahromi V, Abidi H, Jafari Barmak M. 2018. Green tea improves rat sperm quality and reduced cadmium chloride damage effect in spermatogenesis cycle. J Med Life. 11(4):371-380.
Published on Oct 14, 2018

Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review
Buhling K, Schumacher A, Eulenburg CZ, Laakmann E. 2019. Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review. Reprod Biomed Online. 39(2):269-279.
Published on Aug 15, 2019

Quantitative evaluation of spermatozoa ultrastructure after acupuncture treatment for idiopathic male infertility.
Pei J et al Fertil Steril. 2005 Jul;84(1):141-7 Fertility and Sterility CONCLUSION(S): The treatment of idiopathic male infertility could benefit from employing acupuncture. A general improvement of sperm quality, specifically in the ultrastructural integrity of spermatozoa, was seen after acupuncture, although we did not identify specific sperm pathologies that could be particularly sensitive to this therapy.
Published on Jul 1, 2005

Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men
Haghighian HK, Haidari F, Mohammadi-Asl J, Dadfar M. 2015. Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men. Fertil Steril. 104(2):318-24.
Published on Aug 1, 2015

Success of acupuncture treatment in patients with initially low sperm output is associated with a decrease in scrotal skin temperature.
Siterman S, Eltes F, Schechter L, Maimon Y, Lederman H, Bartoov B. Asian J Androl. 2009 Mar;11(2):200-8. doi: 10.1038/aja.2008.4. Epub 2009 Jan 5. Source: Maccabi Fund Complementary Medicine, Kaufman Street, Tel Aviv 68012, Israel. Conclusions: Low sperm count in patients with inflammation of the genital tract seems to be associated with scrotal hyperthermia, and, consequently, acupuncture treatment is recommended for these men.
Published on Jan 5, 2009

The excessive use of antioxidant therapy: A possible cause of male infertility?
Henkel R, Sandhu IS, Agarwal A. 2019. The excessive use of antioxidant therapy: A possible cause of male infertility? Andrologia. 51(1):e13162.
Published on Feb 14, 2019

The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia
Alahmar AT. 2019. The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med. 46(3):112-118.
Published on Sep 15, 2019

The role of fatty acids on ICSI outcomes: a prospective cohort study
Mirabi P, Chaichi MJ, Esmaeilzadeh S, et al. 2017. The role of fatty acids on ICSI outcomes: a prospective cohort study. Lipids Health Dis. 16(1):18.
Published on Feb 14, 2017

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