Female Fertility Studies

Acupuncture blocks cold stress-induced increases in the hypothalamus-pituitary-adrenal axis in the rat.
Eshkevari L, Permaul E, Mulroney SE. 2013. Acupuncture blocks cold stress-induced increases in the hypothalamus-pituitary-adrenal axis in the rat. J Endocrinology, 15;217(1):95-104. CONCLUSIONS: “electronic acupuncture blocks the chronic, stress-induced elevations of the HPA axis hormones and the sympathetic NPY pathway”
Published on Mar 15, 2013

Acupuncture for Depression: A Systematic Review and Meta-Analysis
Armour M, Smith CA, Wang LQ, et al. 2019. Acupuncture for Depression: A Systematic Review and Meta-Analysis. J Clin Med. 8(8):1140.
Published on Aug 14, 2019

Antioxidant supplements and semen parameters: An evidence based review
Ahmadi S, Bashiri R, Ghadiri-Anari A, Nadjarzadeh A. 2016. Antioxidant supplements and semen parameters: An evidence based review. Int J Reprod Biomed. 14(12):729-736.
Published on Dec 14, 2016

Association between phthalate exposure and risk of spontaneous pregnancy loss: A systematic review and meta-analysis
Zhang H, Gao F, Ben Y, Su Y. 2020. Association between phthalate exposure and risk of spontaneous pregnancy loss: A systematic review and meta-analysis. Environ Pollut. 267:115446.
Published on Dec 1, 2020

Chinese Herbal Medicine Fertility Studies
Ried K, Stuart K., Complement Ther Med. 2011 Dec;19(6):319-31. CONCLUSIONS: Our review suggests that management of female infertility with Chinese Herbal Medicine can improve pregnancy rates 2-fold within a 4 month period compared with Western Medical fertility drug therapy or IVF. Assessment of the quality of the menstrual cycle, integral to TCM diagnosis, appears to be fundamental to successful treatment of female infertility.
Published on Dec 19, 2011

Effects and mechanisms of acupuncture in the reproductive system.
Stener-Victorin E, Wu X., Auton Neurosci. 2010 Oct 28;157(1-2):46-51. doi: 10.1016/j.autneu.2010.03.006. Epub 2010 Mar 29. Source: Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Göteborg University, Sweden. elisabet.stener-victorin@neuro.gu.se ABSTRACT: The use of acupuncture to treat reproductive dysfunction has not been well investigated. Only a few clinical studies have been reported, most of which are flawed by poor design and a lack of valid outcome measures and diagnostic criteria, making the results difficult to interpret. Experimental studies, however, show that acupuncture has substantial effects on reproductive function. Here we review the possible mechanisms of action of acupuncture on the reproductive system and its effects on reproductive dysfunction, focusing in particular on polycystic ovary syndrome, the most common endocrine and metabolic disorder in women. Clinical and experimental evidence demonstrates that acupuncture is a suitable alternative or complement to pharmacological induction of ovulation, without adverse side effects. Clearly, acupuncture modulates endogenous regulatory systems, including the sympathetic nervous system, the endocrine system, and the neuroendocrine system. Randomized clinical trials are warranted to further evaluate the clinical effects of acupuncture in reproductive disorders.
Published on Oct 28, 2010

Effects of acupuncture on LIF and IL-12 in rats of implantation failure.
Gui J, Xiong F, Yang W, Li J, Huang G. Am J Reprod Immunol. 2012 May;67(5):383-90. doi: 10.1111/j.1600-0897.2011.01097.x. Epub 2012 Jan 9th Institute of Integrated Traditional Chinese and Western Medicine, Wuhan, Hubei, China. CONCLUSION: Acupuncture could improve the poor receptive state of endometrium by promoting LIF and IL-12 secretion to improve blastocyst implantation.
Published on Jul 9, 2012

Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis
Frederiksen Y, Farver-Vestergaard I, Skovgård NG, Ingerslev HJ, Zachariae R. 2015. Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis. BMJ Open. 5(1):e006592.
Published on Jan 28, 2015

Efficacy of Traditional Chinese Herbal Medicine in the management of female infertility: a systematic review.
Ried K, Stuart K., 2011, Complement Ther Med. 2011 Dec;19(6):319-31. doi: 10.1016/j.ctim.2011.09.003. Epub 2011 Oct 5. CONCLUSIONS: Our review suggests that management of female infertility with Chinese Herbal Medicine can improve pregnancy rates 2-fold within a 4 month period compared with Western Medical fertility drug therapy or IVF. Assessment of the quality of the menstrual cycle, integral to TCM diagnosis, appears to be fundamental to successful treatment of female infertility.
Published on Dec 19, 2011

Evidence for bisphenol A-induced female infertility: a review (2007-2016)
Ziv-Gal A, Flaws JA. 2016. Evidence for bisphenol A-induced female infertility: a review (2007-2016). Fertil Steril. 106(4):827-856.
Published on Sep 15, 2016

Exposure to endocrine disruptors during adulthood: consequences for female fertility
Rattan S, Zhou C, Chiang C, Mahalingam S, Brehm E, Flaws JA. 2017. Exposure to endocrine disruptors during adulthood: consequences for female fertility. J Endocrinol. 233(3):R109-R129.
Published on Jun 1, 2017

Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve
Tong J, Sheng S, Sun Y, Li H, Li WP, Zhang C, Chen ZJ. 2017. Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve. Reproduction. 153(4):443-451.
Published on Apr 14, 2017

Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and susceptibility to recurrent pregnancy loss
Dell'Edera D, L'Episcopia A, Simone F, Lupo MG, Epifania AA, Allegretti A. 2018. Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms and susceptibility to recurrent pregnancy loss. Biomed Rep. 8(2):172-175.
Published on Feb 14, 2018

Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox
Yang L, Lin X, Tang H, et al. 2020. Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell. 19(9):e13206.
Published on Sep 1, 2020

N-Acetyl-Cysteine and l-Carnitine Prevent Meiotic Oocyte Damage Induced by Follicular Fluid From Infertile Women With Mild Endometriosis
Giorgi VS, Da Broi MG, Paz CC, Ferriani RA, Navarro PA. 2016. N-Acetyl-Cysteine and l-Carnitine Prevent Meiotic Oocyte Damage Induced by Follicular Fluid From Infertile Women With Mild Endometriosis. Reprod Sci. 23(3):342-51.
Published on Mar 1, 2016

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR
Yoshino J, Baur JA, Imai SI. 2018. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 27(3):513-528.
Published on Mar 6, 2018

Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes
Miao Y, Cui Z, Gao Q, Rui R, Xiong B. 2020. Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. Cell Rep. 32(5):107987.
Published on Aug 4, 2020

Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence
Radke EG, Glenn BS, Braun JM, Cooper GS. 2019. Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence. Environ Int. 130:104580.
Published on Sep 1, 2019

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy
Enciso M, Sarasa J, Xanthopoulou L, Bristow S, Bowles M, Fragouli E, Delhanty J, Wells D. 2016. Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy. Human Genetics. 135(5):555-568.
Published on May 1, 2016

Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men
Haghighian HK, Haidari F, Mohammadi-Asl J, Dadfar M. 2015. Randomized, triple-blind, placebo-controlled clinical trial examining the effects of alpha-lipoic acid supplement on the spermatogram and seminal oxidative stress in infertile men. Fertil Steril. 104(2):318-24.
Published on Aug 1, 2015

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