Female Fertility Studies

Acupuncture performed around the time of embryo transfer: a systematic review and meta-analysis
Smith CA et al. 2019. Acupuncture performed around the time of embryo transfer: a systematic review and meta-analysis. Reprod Biomed Online. 2019 Mar;38(3):364-379. doi: 10.1016/j.rbmo.2018.12.038. Epub 2019 Jan 2. CONCLUSIONS: Acupuncture may be effective when compared to no adjunctive treatment with increasing clinical pregnancies and live births, but is not an efficacious treatment when compared with sham controls. ("Sham acupuncture is not an effective control, because anytime you put a needle in the body you affect a change", Stephanie Gianarelli)
Published on March 1, 2019

Association between phthalate exposure and risk of spontaneous pregnancy loss: A systematic review and meta-analysis
Zhang H, Gao F, Ben Y, Su Y. 2020. Association between phthalate exposure and risk of spontaneous pregnancy loss: A systematic review and meta-analysis. Environ Pollut. 267:115446.
Published on December 1, 2020

Association of Methylenetetrahydrofolate Reductase C677T and A1298C Gene Polymorphisms With Recurrent Pregnancy Loss in Syrian Women
Al-Achkar W, Wafa A, Ammar S, Moassass F, Jarjour RA. 2017. Association of Methylenetetrahydrofolate Reductase C677T and A1298C Gene Polymorphisms With Recurrent Pregnancy Loss in Syrian Women. Reprod Sci. 24(9):1275-1279.
Published on Sepember 14, 2017

Bisphenol A: an emerging threat to female fertility
Pivonello C, Muscogiuri G, Nardone A, Garifalos F, Provvisiero DP, Verde N, de Angelis C, Conforti A, Piscopo M, Auriemma RS, Colao A, Pivonello R. 2020. Bisphenol A: an emerging threat to female fertility. Reprod Biol Endocrinol. 18(1):22.
Published on March 14, 2020

Chinese Herbal Medicine Fertility Studies
Ried K, Stuart K., Complement Ther Med. 2011 Dec;19(6):319-31. CONCLUSIONS: Our review suggests that management of female infertility with Chinese Herbal Medicine can improve pregnancy rates 2-fold within a 4 month period compared with Western Medical fertility drug therapy or IVF. Assessment of the quality of the menstrual cycle, integral to TCM diagnosis, appears to be fundamental to successful treatment of female infertility.
Published on December 19, 2011

Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study
Chern, CU., Tsui, KH., Vitale, S.G. et al. 2018. Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study. Reprod Biol Endocrinol 16, 90.
Published on Sepember 17, 2018

Effects and mechanisms of acupuncture in the reproductive system.
Stener-Victorin E, Wu X., Auton Neurosci. 2010 Oct 28;157(1-2):46-51. doi: 10.1016/j.autneu.2010.03.006. Epub 2010 Mar 29. Source: Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, Göteborg University, Sweden. elisabet.stener-victorin@neuro.gu.se ABSTRACT: The use of acupuncture to treat reproductive dysfunction has not been well investigated. Only a few clinical studies have been reported, most of which are flawed by poor design and a lack of valid outcome measures and diagnostic criteria, making the results difficult to interpret. Experimental studies, however, show that acupuncture has substantial effects on reproductive function. Here we review the possible mechanisms of action of acupuncture on the reproductive system and its effects on reproductive dysfunction, focusing in particular on polycystic ovary syndrome, the most common endocrine and metabolic disorder in women. Clinical and experimental evidence demonstrates that acupuncture is a suitable alternative or complement to pharmacological induction of ovulation, without adverse side effects. Clearly, acupuncture modulates endogenous regulatory systems, including the sympathetic nervous system, the endocrine system, and the neuroendocrine system. Randomized clinical trials are warranted to further evaluate the clinical effects of acupuncture in reproductive disorders.
Published on October 28, 2010

Effects of Acupuncture on Endometrium and Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome Undergoing In Vitro Fertilization-Embryo Transfer: A Randomized Clinical Trial
Wu, Jm., Ning, Y., Ye, Yy. et al. Effects of Acupuncture on Endometrium and Pregnancy Outcomes in Patients with Polycystic Ovarian Syndrome Undergoing In Vitro Fertilization-Embryo Transfer: A Randomized Clinical Trial. Chin. J. Integr. Med. (2022). Objective To observe the effect of acupuncture on endometrium and pregnancy outcomes in patients with polycystic ovary syndrome (PCOS) infertility undergoing in vitro fertilization-embryo transfer (IVF-ET). Methods Eighty-three patients were randomly assigned to observation group (40 cases) and control group (43 cases) according to the random numbers generated by SPSS software. The patients of the two groups received GnRH agonist long protocol as a routine treatment. In the observation group, acupuncture was given at two acupoint groups for 30 min once every other day. Group 1 included Guanyuan (CV 4), Qihai (CV 6), Zhongji (CV 3), bilateral acupoints Zigong (EX-CA1). Group 2 included Mingmen (GV 4), Yaoyangguan (GV 3), bilateral Shenshu (BL 23) and Ciliao (BL 32). The two groups of acupoints were used alternately. The whole needling process was performed at the time of ovulation induction until the transplantation day and consisted of 3 courses, while the control group did not receive acupuncture interventions. The Gn dosage and Gn stimulation time, endometrial thickness and type (A, B, and C), serum oestradiol (E2) and progesterone (P) levels on the day of injection of human chorionic gonadotropin (hCG), clinical pregnancy rate, as well as live birth rate were observed. Adverse reactions were also be recorded. All patients were followed up for the pregnant rate 14 days after IVF-ET and live birth rate after pregnancy. All adverse reactions (AEs) of acupuncture were recorded during the trial. Results The Gn dosage and Gn stimulation time in the observation group were lower in the observation group than in the control group (P<0.01). The proportion of type A endometrium in the observation group were higher than that in the control group (P<0.05). The serum E2 and P levels on the day of hCG injection was lower and the clinical pregnancy rate was higher in the observation group compared to those in the control group (P<0.05). There was no serious AEs during this trial. Conclusion Acupuncture can improve the proportion of type A endometrium, regulate the levels of serum E2 and P on the day of hCG injection, and improve the pregnancy rate in patients with PCOS infertility undergoing IVF-ET.
Published on April 13, 2022

Effects of acupuncture on LIF and IL-12 in rats of implantation failure.
Gui J, Xiong F, Yang W, Li J, Huang G. Am J Reprod Immunol. 2012 May;67(5):383-90. doi: 10.1111/j.1600-0897.2011.01097.x. Epub 2012 Jan 9. – Institute of Integrated Traditional Chinese and Western Medicine, Wuhan, Hubei, China. CONCLUSION: Acupuncture could improve the poor receptive state of endometrium by promoting LIF and IL-12 secretion to improve blastocyst implantation.
Published on July 9, 2012

Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis
Frederiksen Y, Farver-Vestergaard I, Skovgård NG, Ingerslev HJ, Zachariae R. 2015. Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: a systematic review and meta-analysis. BMJ Open. 5(1):e006592.
Published on January 28, 2015

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