Female Fertility Studies

Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence
Radke EG, Glenn BS, Braun JM, Cooper GS. 2019. Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence. Environ Int. 130:104580.
Published on Sepember 1, 2019

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy
Enciso M, Sarasa J, Xanthopoulou L, Bristow S, Bowles M, Fragouli E, Delhanty J, Wells D. 2016. Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy. Human Genetics. 135(5):555-568.
Published on May 1, 2016

Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture.
Stener-Victorin E, Waldenström U, Andersson SA, Wikland M., Hum Reprod. 1996 Jun;11(6):1314-7. Source: Department of Obstetrics and Gynaecology, Fertility Centre Scandinavia, University of Gothenburg, S-413 45 Gothenburg, Sweden. CONCLUSION: Compared to the mean baseline PI (pulsatility index), the mean PI was significantly reduced both shortly after the eighth EA treatment (P < 0.0001) and 10-14 days after the EA period (P < 0.0001).
Published on June 11, 1996

The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques
Akarsu S, Gode F, Isik AZ, Dikmen ZG, Tekindal MA. 2017. The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques. J Assist Reprod Genet. 34(5):599-605.
Published on May 14, 2017

The Limitation of Randomized Control Trials on the Influence of Acupuncture and In Vitro Fertilization: A Literature Review
Wang, Y., Shen, X., Hu, Y. F., & Sodders, R. (2022). The Limitation of Randomized Control Trials on the Influence of Acupuncture and In Vitro Fertilization: A Literature Review. Medical acupuncture, 34(1), 24–33. Objective: Acupuncture has gained popularity among patients undergoing in vitro fertilization (IVF). However, the beneficial effect of acupuncture for improving IVF success is controversial and debatable. Given that different meta-analyses have come to different conclusions, it is crucial to explore the clinical trials in more detail. This literature review examined the limitation of randomized controlled trials (RCTs) on the influence of acupuncture in IVF. Methods: This review began with 844 studies. The inclusion criteria were studies that had acupuncture treatments in conjunction with IVF. After exclusion criteria were applied, the final number of peer-reviewed studies was 10. Results: There were substantial variations in the results of the 10 RCTs. This seemed to suggest that acupuncture was not effective in conjunction with IVF treatment. However, limitations emerged that might explain these variations in results. Such limitations include timing of acupuncture and point selections; acupuncture not performed by experienced licensed acupuncturists; lack of Traditional Chinese Medicine diagnoses and fixed protocols causing biases; acupuncture dosages; and using sham acupuncture as a control. Conclusions: There is an urgent need for further research into the effectiveness of acupuncture for improving IVF outcomes. This review provides insight into this complex and controversial topic, revealing limitations of the clinical trials that led to different conclusions. If future research can examine acupuncture treatment carefully to resemble real-world clinical practice-having appropriate controls and individualized acupuncture treatments-increasingly positive effects from acupuncture in IVF may be expected.
Published on February 1, 2022

Use of acupuncture in female infertility and a summary of recent acupuncture studies related to embryo transfer.
Stener-Victorin E, Humaidan P., Acupunct Med. 2006 Dec;24(4):157-63. Source: Institute of Neuroscience and Physiolopgy, Sahlgrenska Academy, Göteborg University, Sweden. elisabet.stener-victorin@neuro.gu.se ABSTRACT: During the last five years the use of acupuncture in female infertility as an adjuvant to conventional treatment in assisted reproductive technology (ART) has increased in popularity. The present paper briefly discusses clinical and experimental data on the effect of acupuncture on uterine and ovarian blood flow, as an analgesic method during ART, and on endocrine and metabolic disturbances such as polycystic ovary syndrome (PCOS). Further it gives a summary of recent studies evaluating the effect of acupuncture before and after embryo transfer on pregnancy outcome. Of the four published RCTs, three reveal significantly higher pregnancy rates in the acupuncture groups compared with the control groups. But the use of different study protocols makes it difficult to draw definitive conclusions. It seems, however, that acupuncture has a positive effect and no adverse effects on pregnancy outcome.
Published on December 24, 2006

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